With your space dedicated to Nook Store purchases, you'll need to be aware of some limitations. Remember that your Nook won't let you browse Amazon.com for books or media; you're strictly buying from Barnes & Noble. While that probably isn't going to be a huge issue -- Barnes & Noble isn't exactly lacking product, boasting 2.5 million titles in the Nook Store -- it is something to keep in mind, depending on where you're used to buying or looking for books.
At one time, brand loyalty was important. Originally, Barnes & Noble only had a partnership with Marvel comics (due to a little company called Amazon snapping up DC Comics digital rights), so you were out of luck if you wanted a Green Lantern comic on your Nook. However, in 2012, Barnes & Noble struck a deal with DC Comics to get digital content. Incidentally, that also means Barnes & Noble is restocking their physical shelves with DC comics. If a publisher has exclusive digital rights with Amazon, Barnes & Noble will quickly banish any physical copies of those books from its stores, which is a pretty persuasive tactic for getting publishers to make a deal with the bookseller.
Remember how we told you earlier that Barnes & Noble still wanted to get you in their stores? Well, they're doing a darn good job of it by leveraging their Nook Store apps. One promotion offered Angry Birds addicts the opportunity to move up a level free (when you'd normally have to pay $1). The catch? The bonus was only awarded at no cost if it was accessed via WiFi at a Barnes & Noble location.
Speaking of apps, one downside of the Nook Tablet is that you don't have full access to all apps available for Android. Instead, the Nook Store offers a cultivated library. It's growing, but there are significant holes. Finding a Major League Baseball app proves fruitless in the Nook Store, while it's a free Android offering. While we're not condoning it, it's also possible to find ways to access and download non-cultivated material on your tablet.