Think about your computer habits. What part of your Mac do you touch the most? For many, it's the mouse, which means it is also has the most germs. To clean your Mac mouse, first properly disconnect it from your computer by safely ejecting it, unplugging it and taking out the batteries (depending on what type you have). Apple suggests using a Lysol or Clorox wipe to really disinfect the top of the device [source: Apple.com].
It's important when cleaning the mouse to use a soft, lint-free cloth and not too much cleanser. If you use too much, you may get cleaner into the cracks of the mouse, which will damage it permanently. If you're using a disinfectant wipe, make sure you ring it out first. If you're using a cleaner with a cloth, put the cleaner on the cloth; never spray it directly on the mouse.
After cleaning the top surface of the mouse, if your mouse has a track ball, turn it over and rub the track ball back and forth on a clean, white piece of paper. If your mouse uses a laser, be very careful and clean this area with a dry lint cloth only. Don't use any cleaners, as they may damage the sensitivity of the laser. Finally, try to avoid taking the mouse apart. The Mac Mighty Mouse is actually glued together, so taking it apart would permanently damage the device [source: Osborne].